This invention relates to the inhibitory activity of the combination of a natural chem. entity Artocarpin with standard drug gentamycin against different multi drug-resistant and susceptible strains of S. aureus. (Formula I) The synergy combination of the disclosed compound AH-5 with gentamycin is confirmed using checker-board assay, by determining the fractional inhibitory concentration The FIC index of the combination 1/4th of the MIC of gentamycin, which indicates the synergistic behavior. Further, the above-mentioned combination is capable of inhibiting the complex bacterial communities that are more resistant towards antibiotics. It is showing an anti-biofilm property by reducing the bacterial biomass by 9.7%, as compared to the untreated, which is far better than the existing drugs levofloxacin 1X MIC (6.8%) and Vancomycin 1X MIC (6.3%).