Mismanagement of infectious wastes such as test samples can cause the transmission of microbes/toxins/viruses leading to spread of  contagious and infectious diseases to a susceptible host upon contamination and occupational exposure. Adding a flocculating or  solidifying agent to liquid waste reduces the risk of spills and aerosolization. If the system contains a disinfectant, it may be possible  to dispose the waste as non-regulated medical waste, which is less expensive than red-bagging. Solid wastes such as cotton, sharps as  well as tissues may also lead to spread of infections and simple absorbers or hypochlorites are not always capable of treating such  solid wastes. The present invention intends to disclose a process for in situ flocculation followed by solidification of biomedical waste  that is capable of simultaneously treating and disinfecting solid and fluid samples. The process comprises of the addition of the waste  samples to an alkaline aqueous solution of metal silicates followed by the addition of an organic or inorganic acid for flocculation and  a solid metal oxide or phosphate at a defined volumetric and/or weighted composition leading to instantaneous solidification with  99.9% microbial disinfection and an all-in-one disinfecting device for treatment of biomedical waste.