Mismanagement of infectious wastes such as test samples can cause the transmission of microbes/toxins/viruses leading to spread of  contagious and infectious diseases to a susceptible host upon contamination and occupational exposure. Adding a solidifying agent to  liquid waste reduces the risk of spills and aerosolization. If the solidifying agent contains a disinfectant, it may be possible to dispose  the waste as non-regulated medical waste, which is less expensive than red-bagging. Solid wastes such as cotton, sharps as well as  tissues may also lead to spread of infections and simple absorbers or hypochlorites are not always capable of treating such solid  wastes. The present invention intends to disclose an improved process for the efficient solidification of biomedical waste that is  capable of simultaneously treating and disinfecting solid and fluid samples. The process comprises of the addition of the waste  samples to an alkaline aqueous solution followed by the addition of a solid material at a defined volumetric and/or weighted  composition leading to instantaneous solidification with 99.9% microbial disinfection and an all-in-one disinfecting device for  treatment of biomedical waste.