The present invention relates to the process for the preparation of Nitazoxanide and intermediates thereof. . The invention explores  readily available starting materials with reaction conditions that are suitable for industrial scale applications. The present invention  discloses, a single vessel process to prepare 5-nitrothiazol-2-amine starting from a very basic starting material 1,1-dimethoxy-N, N- dimethylmethanamine . Overall intermediates throughout the process is free from column chromatography and the final product  Nitazoxanide is purified by precipitation. All the synthesized compounds were confirmed by various spectroscopic techniques such as  Fourier transform infrared spectroscopy, 1H NMR, 13C NMR, HRMS and elemental analysis.